![]() ![]() Random-effects meta-analyses were conducted for treatment harms. Prostate cancer and all-cause mortality false-positive screening results, biopsy complications, overdiagnosis adverse effects of active treatments. Two investigators independently rated study quality. One investigator abstracted data a second checked accuracy. Searches of PubMed, EMBASE, Web of Science, and Cochrane Registries and Databases from July 1, 2011, through July 15, 2017, with a surveillance search on February 1, 2018.Įnglish-language reports of randomized clinical trials (RCTs) of screening cohort studies reporting harms RCTs and cohort studies of active localized cancer treatments vs conservative approaches (eg, active surveillance, watchful waiting) external validations of prebiopsy risk calculators to identify aggressive cancers. To systematically review evidence on prostate-specific antigen (PSA)-based prostate cancer screening, treatments for localized prostate cancer, and prebiopsy risk calculators to inform the US Preventive Services Task Force. Prostate cancer is the second leading cause of cancer death among US men. ![]()
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